ABL provides services for pharmaceutical drug discovery and all preclinical and clinical development phases.

Drug discovery

Together with a few other companies ABL participates in Integrex Research, which is an integrated Drug Discovery company. Detailed information can be found on the Integrex website: http://www.integrexresearch.com. Within Integrex research, ABL is performing all in-vitro work.

Bioanalysis

Bioanalysis is the main service offered for both the preclinical and clinical development phases. ABL works both for human and veterinary pharmaceutical companies and contract research organizations. For this work, ABL is able to claim GLP and/or GCP.

Main techniques are chromatography and immunochemistry.

ABL has experience with all possible human and animal biological matrices, including blood, plasma, serum, urine, feces, tissues and milk.

To give an idea of our capabilities, you can have look at our lists of recently validated generic methods for both human and veterinary applications.

Chromatography.

Besides all the classical HPLC-UV/PDA/Fluorescence/ECD/flow-ionization possibilities (the latter for tracer studies), ABL has the disposal of eight LC-MS/MS systems (all Sciex quadropole tandem mass spectrometry systems). Our main platform is the Sciex API 4000 system, including one API4000-Qtrap). For more sensitivity, also a Sciex API 5500-Qtrap is available. The Qtraps are also very helpful in qualitative metabolism studies. Recently the API5500 Q-trap was also equipped with the SelexION option. With this ion-mobility option even more selectivity and sensitivity is available. Applying the SelexION option, the first application measuring femtograms per mL has recently been validated.

Immunochemsitry

Started in 1969 as a laboratory for radioimmunoassay, ABL has a long track record of performing immunoassays for PK measurements, biomarkers and immunogenicity.

Main techniques are:

  • Enzyme Linked Immuno Assay (ELISA)
  • Time Resolved Fluarescence Immuno Assay (TRFIA; Autodelfia)
  • Radio Immuno Assay (RIA)
  • Alphalisa
  • Western Blotting